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Teaching Curriculum: Adverse Drug Reactions
Priorities:
Pediatrics 1, Internal Medicine 1
Family Practice 1, Student 2
OBJECTIVES
Upon completion of this rotation, the rotator should be able to:
- Classify adverse drug reactions and give examples, including:
- toxicity
- intolerance
- side effects
- idiosyncrasy
- drug allergy
- drug interactions
- Explain the pathophysiology of drug allergy
- Type I, immediate hypersensitivity (IgE-mediated) drug reaction with several examples
- Type II, cytotoxic-type drug reactions with examples
- Type III, serum sickness: Arthus-type drug reaction with examples
- Type IV, cellular hypersensitivity-type drug reaction with examples
- Using penicillin as a model,
- define hapten
- list several different penicillin reactions, both immunologic and nonimmunologic
- Explain the roles of clinical history, physical examination, and laboratory testing in the evaluation of adverse drug reactions
- Discuss skin testing for penicillin allergy
- Describe reactions to local anesthetics and use of graduated dose therapeutic trial
- Identify several drugs that have been implicated in anaphylactic reactions
- Know where (and when) to report suspected adverse reactions to medication.
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