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New Research - October 2009
Insulin like growth factor and remodelling in asthma
Summary
The investigators involved in this project had previously shown that insulin-like growth factor (IGF) binding proteins contribute to the extracellular matrix deposition in idiopathic pulmonary fibrosis. They therefore wished to see if these molecules contributed to the airway remodeling in asthma. They evaluated levels of insulin growth factor binding proteins (IGFBP-3) in tissue and bronchoalveolar lavage fluid from asthmatics at baseline and 48 hours after allergen challenge. They also assessed the presence of this molecule in reparative epithelium in an in vitro wounding assay as well as conditioned media from cytokine- and growth factor-stimulated primary epithelial cells.
The concentration of IGFBP-3 was increased in bronchoalveolar lavage fluid after allergen challenge as well as in epithelium in an in vitro wounding assay, and in conditioned medium of primary epithelial cell cultures that were stimulated with insulin growth factor 1 (IGF-1).
These observations prompted the authors to conclude that IGFBP-3 from IGF-1-stimulatd airway epithelial cells plays a role in allergic airway remodeling.
Reference
Veraldi KL, et al. Role of insulin-like growth factor binding protein-3 in allergic airway remodeling. American Journal of Respiratory and Critical Care Medicine 2009; 180:611-617.
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