AAAAI Allergy & Asthma Medication Guide: Leukotriene Modifiers

Last updated: November 2006

Asthma/ Long-Term Control Medication: Leukotriene Modifiers: these medications reduce the effect of leukotrienes. Leukotrienes are responsible for the swelling and constriction of the bronchial tubes as well as different cell activities that occur in asthma.

Generic name

Photo

Brand name

Use

Usual dosage

Tips and Product Link

Montelukast

Singulair
4 or 5 mg Chewable Tablets
4 mg Oral Granules
10 mg tablet

To prevent and treat asthma
Age 2 and above

Age 2 to 5: One 4 mg tablet once a day
Patients 12 to 23 months:
One packet of 4-mg oral granules daily.
Age 6 to 14: One 5 mg tablet once a day
Age 15 and older: 0ne 10 mg tablet once a day

Best to take in the PM

OK with meals

Not to be used as an asthma relief medication.

Meant to be taken daily to prevent symptoms.

Oral granules can be administered mixed with a spoonful of cold or room temperature soft food. Use within 15 minutes of opening the packet.
Tested with applesauce, carrots, rice or ice cream.
Singulair Package Insert

Pregnancy Category B

Zafirlukast

Accolate 10 or 20 mg tablets

To prevent and treat asthma ages 5 and above.

Age 5 to 11: One 10 mg tablet twice a day.

Age 12 and older:
One 20 mg tablet twice a day.

Take one hour before meals or 2 hours after meals
Not to be used as an asthma relief medication.
Meant to be taken daily to prevent symptoms.
Accolate Package Insert

Pregnancy Category B

Monitor Liver Enzymes

zileuton

Zyflo Filmtab Tablets 600 mg

To prevent and treat asthma ages 12 and older.

Age 12 and older: one 600 mg tablet four times a day.

May take with meals and bedtime (4 times a day).
Can raise liver enzymes, measure these before first use and periodically during use.
Zyflo Package Insert
Pregnancy Category C
Zyflo Package Insert

 



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